Top Funding Rounds Led by AI, Cybersecurity and Health This Week

Keep track of the largest startup funding deals in 2026 with our curated list of $100 million-plus venture investments directed at U.S.-based companies by visiting The Crunchbase Megadeals Board.

This weekly feature breaks down the top 10 announced funding rounds in the U.S. You can review last week’s biggest funding deal roundup here.

This week brought an abundance of major startup capital raises, highlighted by a pair of $400 million financings for cybersecurity unicorns Cyera and Island. The remainder of the week’s largest investments spanned high-profile sectors including foundational AI, drug discovery, neurotech, and cloud seeding.

1. Island, $400M, cybersecurity: Island, a creator of tools for secure enterprise digital operations, secured $400 million in Series F financing. Led by Evolution Equity Partners, the round pushed the Dallas-based firm to a $6.4 billion valuation, which is more than double its worth from 2024.

2. Cyera, $400M, cybersecurity: Cyera, a developer of enterprise data security tools that govern both humans and AI agents, gathered $400 million in Series G extension funding. Evolution Equity Partners led the round with backing from Goldman Sachs Growth Equity, bringing New York-based Cyera’s total capital raised to $2.7 billion, according to Crunchbase data.

3. Snorkel AI, $350M, foundational AI: San Francisco-based Snorkel AI, which supplies tools for frontier laboratories and artificial intelligence teams to build specialized training data and environments, locked down $350 million in Series E funding. Insight Partners and S32 spearheaded the round, giving the 7-year-old enterprise a $3.2 billion valuation alongside more than $375 million in annual recurring revenue.

4. Enveda, $311M, biotech: Enveda, an artificial intelligence-driven drug discovery startup, finalized $311 million in Series E financing led by Catalio Capital Management with participation from numerous new and existing backers. This capital injection raises the Boulder, Colorado-based company’s total funds secured since launch past $845 million.

5. Precision Neuroscience, $250M, neurotech: New York-headquartered Precision Neuroscience, a company specializing in brain-computer interface technology, obtained $250 million in Series D funding. Pershing Square and the Ackman Oxman Institute served as the lead investors.

6. Hubble Network, $200M, wireless communications: Hubble Network, which operates a satellite system that brings connectivity to Bluetooth devices, brought in $200 million via a Series C financing. Smith Point Capital led the investment, establishing a $6 billion valuation for the Seattle-based organization.

7. Rightway, $155M, pharmacy benefits: New York-based Rightway, a provider of care navigation and pharmacy benefits, captured $155 million in Series E funding spearheaded by Francisco Partners. The startup intends to allocate a portion of the funds toward scaling its artificial intelligence capabilities.

8. (tied) Rainmaker, $100M, cloud seeding: El Segundo, California-based Rainmaker, an enterprise dedicated to atmospheric research and generating new freshwater through cloud seeding, secured $100 million in Series B funding. Contributors to the round include Noa, Upfront Ventures, DCVC, Lowercarbon Capital, and Dream Ventures.

8. (tied) Numeral, $100M, tax compliance: San Francisco-headquartered Numeral, an artificial intelligence-driven sales tax compliance platform, completed a $100 million Series C round led by Insight Partners.

8. (tied) Micro1, $100M, AI data: San Francisco-based Micro1, a supplier of artificial intelligence training data to leading AI labs, reportedly secured a fresh funding round exceeding $100 million at a $4 billion valuation, citing information from a Forbes report referencing individuals close to the transaction.

Methodology

We monitored the largest announced rounds within the Crunchbase database secured by U.S.-based companies covering the timeframe of Sept. 19–25, 2026. While the vast majority of announced rounds populate the database, a minor time lag can occur when deals are disclosed late in the week.

Illustration: Dom Guzman